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Wegovy vs Saxenda – Key Differences – Which Weight Loss Treatment is Better?

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Thinking about weight loss pens? You’re not alone. Millions face weight management challenges, but injectable medications like Wegovy and Saxenda offer promising options. However, these two popular choices have key differences to consider. This blog will explore the effectiveness, dosing, and availability of Wegovy vs Saxenda, so you can navigate your weight loss journey with confidence!

Overview

FeatureWegovySaxenda
Active IngredientSemaglutideLiraglutide
Frequency of InjectionOnce WeeklyDaily
Effectiveness(Avg. Weight Loss)15.85%(Study)-6.4%(Study)

GLP-1 Medication for Weight Management

GLP-1, also known as glucagon-like peptide-1, is a natural hormone synthesized in the gut. It plays a pivotal role in regulating both blood sugar levels and appetite. Upon meal consumption, the release of GLP-1 triggers a signal to the brain inducing a sense of fullness, thereby decreasing hunger and fostering feelings of satisfaction.

Glucagon-like peptide-1

These medications replicate the actions of native GLP-1, prolonging the sensation of satiety and reducing calorie intake. The outcome? A potential avenue for substantial weight loss, particularly when complemented by a balanced diet and regular exercise regimen.

Several GLP-1 medications are accessible in the UK, recognizable by their brand names. Examples include Liraglutide (Saxenda), semaglutide (Wegovy, Ozempic), and Tirezepatide (Mounjaro) are used as weight loss treatment. It’s imperative to consult a healthcare professional to determine the suitability of a GLP-1 medication for you, tailored to your specific needs.

Understanding Wegovy and Saxenda:

Both Wegovy and Saxenda mimic a natural hormone in your gut called GLP-1, which plays a role in appetite and blood sugar control. By mimicking this hormone, these medications help you feel fuller for longer, leading to reduced calorie intake and aid in weight loss treatment. 

Saxenda has been a weight-loss medication option since 2017, while Wegovy became available in September 2023, offering another weight-loss solution in the UK. Both medications are manufactured from the same company, Novo Nordisk.

What is the difference between wegovy and saxenda?

  • Active Ingredient: Wegovy uses semaglutide, while Saxenda uses liraglutide.

  • Dosing: Wegovy offers a weekly injection with gradual dose increases, while Saxenda requires daily injections with similar dose adjustments. This difference can significantly impact your treatment preference.

Similarities Between Wegovy and Saxenda:

  1. Mechanism of Action: Both target the GLP-1 system to regulate appetite and promote feelings of fullness.
  2. Delivery Method: Both come in single use pre-filled pens for convenient self-injection.
  3. Side Effects: Both can cause nausea, vomiting, diarrhea, and constipation. These are usually mild and temporary.
  4. Availability: Both require a prescription and are typically recommended for people with:
    • A Body Mass Index (BMI) between 27 kg/m² and 30 kg/m² with a weight-related health condition like diabetes.
    • A BMI of 30 kg/m² or more, even without a weight-related health condition

Managing Wegovy Vs Saxenda Side Effects:

Wegovy (semaglutide) and Saxenda (liraglutide) are weight management medications that can cause side effects. Studies suggest that Wegovy may be easier to tolerate than Saxenda. In one study, fewer people taking Wegovy stopped treatment due to side effects compared to those taking Saxenda (13.5% vs. 27.6%).

That said,  most people in both groups (80%) experienced common side effects, mainly gastrointestinal (GI) issues like upset stomach, diarrhea, or constipation.

To help minimize these side effects and allow you to adjust to the medication, with the dosage of both Wegovy and Saxenda is gradually increased over time. This slow increase gives your body a chance to get used to the drug.

Switching Between Medications:

Consulting a healthcare professional is crucial before switching from Saxenda to Wegovy. They can assess your individual needs, weight loss goals, and response to the current medication to determine the most suitable approach.

Important Considerations:

  • Diet and Exercise: Remember, these medications are not a magic solution. Sustainable weight loss requires a combination of a healthy diet, regular exercise, and lifestyle modifications alongside medication.

  • Weight Loss Injections in UK: Both Wegovy and Saxenda are available in the UK and require a prescription. Consult a healthcare professional experienced in weight management to create a personalized plan.

Where to buy weight loss injections in UK?

Prescription weight loss medications can vary in cost depending on dosage. We at Priman are committed to offering weight loss injections at competitive rates to support your weight loss journey.

Can you get Saxenda and Wegovy on the NHS?

Yes, both Saxenda and Wegovy are technically available on the NHS, but with some important limitations:

Referral required: The weigh loss injections won’t be prescribed directly by your GP. Instead, you’ll need to be referred to a specialist weight management service, typically a tier 3 service. These programs are designed for people with severe obesity who haven’t had success with other weight loss methods.

Availability: There have been ongoing supply issues with Saxenda in the UK, so even with a referral, it may not be readily available.

Eligibilty criteria: Recommended for people with:
A Body Mass Index (BMI) between 27 kg/m² and 30 kg/m² with a weight-related health condition like diabetes.
A BMI of 30 kg/m² or more, even without a weight-related health condition

What is the best injection for weight loss – Wegovy vs Saxenda?

  • Wegovy: Ideal if you prefer weekly injections and potentially greater weight loss efficacy.
  • Saxenda: A good choice if you’re comfortable with daily injections and might have a lower tolerance for side effects.

Conclusion

Wegovy and Saxenda are promising options for weight management, but they are not one-size-fits-all solutions. Consulting a healthcare professional is vital to determine the most appropriate option for your individual needs. This discussion should consider your weight loss goals, medical history, and preferred injection frequency. Remember, long-term weight loss success hinges on a combination of healthy lifestyle modifications along with diet injections.

Ready to take charge of your weight loss? Let’s get started with Priman!

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