Having trouble losing those extra kilos? If so, you might have come across Xenical, a weight-loss medication. In this blog, we’ll delve into how Xenical works its magic, its potential benefits, and essential considerations for using it safely and effectively in the UK.
What is Xenical?
Xenical is a prescription medication containing the active ingredient orlistat. It’s designed to aid in weight loss for individuals who are obese or overweight. Unlike appetite suppressants, Xenical doesn’t directly affect your brain’s hunger signals. Instead, it works within your digestive system to tackle dietary fat.
The Science Behind Xenical
To understand how Xenical operates, we need a quick biology lesson. Normally, when you eat a meal, your body releases enzymes called lipases. These enzymes break down dietary fat into smaller molecules that can be absorbed into your bloodstream. Xenical steps in as a lipase inhibitor, essentially blocking these enzymes from doing their job.
Xenical Vs Orlistat & Dosages?
There is no difference between Orlistat and Xenical in terms of their active ingredient, dosage, or mode of action. The only distinction is that:
- Xenical is the brand name version of the medication, originally manufactured by Roche.
- Orlistat is the generic name for the same medication, produced by various pharmaceutical companies after the original patent expired.
Available Doses:
- Both orlistat and Xenical are available in the same dosage: 120mg capsules.
- This is the standard dose taken three times a day with meals containing fat.
Mode Of Action
Both orlistat and Xenical work in the same way by inhibiting the action of lipases, enzymes that break down dietary fat in the intestines. This leads to a reduction in the amount of fat absorbed by the body, resulting in weight loss. Specifically:
- Lipase inhibition: Orlistat/Xenical binds to lipases in the gut, preventing them from breaking down dietary fat.
- Reduced fat absorption: The undigested fat is then eliminated from the body through bowel movements.
- Calorie reduction: Since fat is not absorbed, the overall calorie intake is reduced, leading to weight loss over time.
How Does Xenical Prevent Fat Absorption?
When you take Xenical with a meal, it binds to the lipases in your gut. This prevents them from breaking down a significant portion (around 30%) of the fat you consume. The undigested fat then passes through your digestive system and is eliminated from your body through your stool.
Benefits of Xenical
- Weight Loss Aid: Xenical can significantly contribute to weight loss when combined with a healthy diet and exercise. Clinical trials have shown that a study of 676 patients compared the weight loss achieved with different doses of orlistat with that achieved with a placebo, with 37 % of patients taking 120mg of orlistat achieving more than 10% weight loss over a 24-week period compared with just 19% in the placebo group.
- Reduced Risk of Weight Regain: Not only can Xenical help you lose weight, but it may also make it easier to keep the weight off. Studies suggest that people who continue taking Xenical after reaching their target weight are less likely to regain the lost pounds.
- Improved Health Markers: Alongside weight loss, Xenical can positively impact various health markers. A review conducted in 2020, mentioned it can lead to lower blood pressure, reduced cholesterol levels, and improved blood sugar control, potentially lowering the risk of heart disease and type 2 diabetes.
Who Should Consider Xenical?
Xenical is generally prescribed for adults who are classified as obese (BMI of 30 or higher) or overweight (BMI of 28 or higher) with additional weight-related health conditions such as high blood pressure or diabetes. It’s crucial to consult with your healthcare professional to determine whether Xenical is a suitable option for you.
Important Considerations and Side Effects
- Diet and Exercise: Xenical is most effective when used alongside a balanced, reduced-calorie diet and regular exercise.
- Fat-Soluble Vitamins: Because Xenical interferes with fat absorption, it can also hinder the absorption of certain fat-soluble vitamins (A, D, E, and K). Your doctor may recommend taking a multivitamin supplement to compensate.
- Side Effects: Xenical can cause gastrointestinal side effects, including oily or fatty stools, increased bowel movements, urgency to go to the toilet, and flatulence. These side effects are often mild and tend to decrease over time.
Where to Get Xenical in the UK
Xenical is a prescription-only medication in the UK. You’ll need to consult with your healthcare professional to determine your eligibility and receive a prescription. It’s available in most pharmacies across the country.
Is Xenical Right for You?
Xenical can aid in weight loss journey, but it’s essential to make an informed decision. Talk to your healthcare professional to discuss your individual circumstances, goals, and any potential risks or benefits of using Xenical. Remember, a holistic approach to weight management that includes diet, exercise, and lifestyle modifications is key to long-term success.
References:
Bansal, A. B., Patel, P. and Al Khalili, Y. (2024) Orlistat. StatPearls Publishing.
Jain, S. et al. (2011) “Evaluation of efficacy and safety of orlistat in obese patients,” Indian journal of endocrinology and metabolism, 15(2), p. 99. doi: 10.4103/2230-8210.81938.
Kelley, D. E. et al. (2002) “Clinical efficacy of orlistat therapy in overweight and obese patients with insulin-treated type 2 diabetes,” Diabetes care, 25(6), pp. 1033–1041. doi: 10.2337/diacare.25.6.1033.
Sahebkar, A. et al. (2018) “Effects of orlistat on blood pressure: a systematic review and meta-analysis of 27 randomized controlled clinical trials,” Journal of the American Society of Hypertension: JASH, 12(2), pp. 80–96. doi: 10.1016/j.jash.2017.12.002.
Van Gaal, L. F. et al. (1998) “Efficacy and tolerability of orlistat in the treatment of obesity: a 6-month dose-ranging study,” European journal of clinical pharmacology, 54(2), pp. 125–132. doi: 10.1007/s002280050433.
Xenical 120 mg hard capsules – Summary of Product Characteristics (SmPC) – (emc) (no date) Org.uk. Available at: https://www.medicines.org.uk/emc/product/2592/smpc
